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Adipose etrogenisation and other anthropological aspects of obesity
Novák, Jan ; Sedlak, Petr (advisor) ; Bezdíček, Ondřej (referee) ; Bendlová, Běla (referee)
This work presents an anthropological view of obesity. It introduces the concept of adipose estrogenization and describes its relationship to pelvic morphology. Further, secular changes in the prevalence of latent obesity, the consequences, and the etiology of this condition are described. The work also validates tools for assessing chronotype, subsequently associating these metrics with sociodemographic factors, including obesity. The key part of this project present study focused on changes in the morphology of the bony pelvis in the context of pubertal history of obesity. It is a longitudinal study (n = 238) with an anthropometric examination after 8 years and an estimation of sex hormones. The main observation was that adult men with a history of obesity had more gynoid (relatively wider) pelvic bone morphology and altered levels of sex hormones, i.e., reduced testosterone levels and an increased relative proportion of estradiol to testosterone, i.e., estrogenization. This was manifested with habitual pelvic feminization, which serves as a marker of estrogenization and a retrospective marker of obesity. In the context of this study, a Letter to the Editor is added as a correction to the publication, interpreting these findings as a possible explanation for the shorter second stage of labor in...
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The Importance of Circadian Rhythms in Humans with a Focus on Adolescents
Kolářová, Michaela ; Vančata, Václav (advisor) ; Ehler, Edvard (referee)
The aim of the presented diploma thesis is a detailed outline of the meaning of circadian rhythms in adolescence. Circadian rhythms appear in early childhood, but undergo many changes during lifetime. While in early childhood the waking and sleeping cycle shifts to an earlier time, during adolescence it is quite the opposite and the cycle is shifted a few hours later and in older age the cycle even returns to an earlier state. Adolescence is associated with the most significant changes and increased demands on study, independence and generally more overload at the expense of quality and adeqaute sleep, which not only causes circadian rhythms to dissipate and shift dramatically, which such as health. For adolescents, the delayed phase is naturally correlated with sexual development, with sleep patterns being controlled by the biological component. Respecting physiological changes in adolescence and striving for institutional changes seem to be the most appropriate therapies instead of forcing patterns basen on institutional and parental needs, which only undermines adolescent body chemistry, results in insufficient and poor quality sleep for functioning and healthy physiological development of adolescents.
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The Importance of Circadian Rhythms in Humans with a Focus on Adolescents
Kolářová, Michaela ; Vančata, Václav (advisor) ; Ehler, Edvard (referee)
The aim of the presented diploma thesis is a detailed outline of the meaning of circadian rhythms in adolescence. Circadian rhythms appear in early childhood, but undergo many changes during lifetime. While in early childhood the waking and sleeping cycle shifts to an earlier time, during adolescence it is quite the opposite and the cycle is shifted a few hours later and in older age the cycle even returns to an earlier state. Adolescence is associated with the most significant changes and increased demands on study, independence and generally more overload at the expense of quality and adeqaute sleep, which not only causes circadian rhythms to dissipate and shift dramatically, which such as health. For adolescents, the delayed phase is naturally correlated with sexual development, with sleep patterns being controlled by the biological component. Respecting physiological changes in adolescence and striving for institutional changes seem to be the most appropriate therapies instead of forcing patterns basen on institutional and parental needs, which only undermines adolescent body chemistry, results in insufficient and poor quality sleep for functioning and healthy physiological development of adolescents.
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Circadian regulation of sleep during ontogenesis in humans
Grieblová, Adéla ; Sumová, Alena (advisor) ; Soták, Matúš (referee)
The circadian system has evolved as an adaptation to periodically changing conditions on Earth. In mammals, and therefore in humans, the circadian system consists of the central and perip- heral oscillators generating a circadian rhythm. One of the most significant process exhibiting circadian rhythm is the sleep-wake cycle. Sleep is regulated by cooperation of circadian and homeostatic process. There are changes in circadian regulation of sleep during ontogenesis in human. The changes mainly releate to chronotype, i.e., to the diurnal preferences of activity and sleep. In the first years of life, there is a typical morning chronotype. In the end of first decade of life, the circadian phase begins to delay and reaches its maximal eveningness during ado- lescence. In adulthood, the preference changes again toward morning chronotype and reaches extreme morningness in elderly. Changes in circadian regulation of sleep during ontogenesis depend not only on age, but also on sex. 1
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The Circadian System and Sleep in Individuals with ADHD
Nejedlý, Martin ; Skálová, Kateřina (advisor) ; Honzlová, Petra (referee)
Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with sleep disorders and abnormalities of the circadian system. In recent studies, ADHD has been linked to late chronotype and delayed sleep phase disorder, clock gene polymorphisms, geographic variation in solar irradiation, longer sleep latency, and impaired sleep quality. However, research findings in children with ADHD often differ from those in adult patients. A new diagnostic category, ADHD-SOM, has been proposed to describe individuals whose symptoms are partially caused by chronic sleep issues. However, most of the evidence is correlational. The thesis summarizes research on sleep and circadian correlates of ADHD and some of the potential mechanisms explaining these associations. Chronotherapy and sleep interventions are promising methods of adjunctive ADHD treatment.
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Chronotypes and Social Jet Lag Related to Obesity
Halászová, Andrea ; Fárková, Eva (advisor) ; Červená, Kateřina (referee)
In nature we can observe plenty of actions which show some kind of regularity as they repeat with a certain period. The circadian rhythm with its period of approximately one day belongs among these. The circadian rhythm is synchronized mainly by light, but there are also many other internal and especially external synchronizers such as the society we live in. In an organism many processes show circadian rhythmicity, but everyone has the rhythm adjusted individualy, thus called chronotype. It's indeed very important to note that living in harmony with the chronotype is essential. Social jet lag is the term for a long-term disbalance and circadian desynchrony as a consequence of the need to adjust this individual circadian preference to the regime set by the society we live in. Many of recent studies support the findings, that social jet lag might have an impact on health and could participate in development of some of the lifestyle diseases such as obesity. Therefore it should be found beneficial to apply those finding in a clinic practise not only in order to help with an efficient treatment of obesity and its consequences but also in preventing it.
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Circadian preferences with emphasis on school-age children
Kasalová, Michaela ; Janečková, Denisa (advisor) ; Drda Morávková, Alena (referee)
Bakalářská práce: Cirkadiánní preference se zaměřením na děti žákovského věku Řešitel: Michaela Kasalová Vedoucí práce: PhDr. Denisa Janečková, Ph.D. Abstract: Chronobiology (name comes from a Greek word chronos = time) is a scientific field engaged in biological rhythms that have a specific cycle with a different length of period. The most important rhythms for a human body are circadian rhythms with a period approximately 24 hours. These rhythms influence individual timing of physiological, biochemical and psychological variables technically called chronotypes. Objectives of this bachelor's work are to map the chronotypes from a historical view and to outline individual types, their specifications, their biological principle and their connection with the circadian rhythms and a sleeping cycle. Differences between chronotypes are not only among individual persons but they are changing during specific ages, therefore I focus on school-age children. Today's school system forces pupils to a certain rhythm, not necessarily well functioning with their internal natural biorhythm, and can influence results as well as study options.
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